A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
نویسندگان
چکیده
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
منابع مشابه
Commentary: A new dawn for genetic epidemiology?
2003;32:1–22. 4 Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:89–94. 5 Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724–26. 6 Brennan P, McKay J, Moore L et al. Uncommon CHEK2 mis-sense...
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ورودعنوان ژورنال:
- Science
دوره 316 5826 شماره
صفحات -
تاریخ انتشار 2007